The International Workshops on Genotoxicity Testing (IWGT): history and achievements.

An in vitro model of chemotherapeutic damage to mesenchymal stem cells

s of the 33 Annual Meeting of the United Kingdom Environmental Mutagen Society, 12 14 July 2010 at the University of Derby, UK. 1. Photogenotoxicity – science without application? Daniel Bauer Novartis Institutes of BioMedical Research, Preclinical Safety, 4002 Basel, Switzerland In 1999 the International Workshop on Genotoxicity Test Procedures prepared recommendations for photogenotoxicity te...

IWGT report on quantitative approaches to genotoxicity risk assessment II. Use of point-of-departure (PoD) metrics in defining acceptable exposure limits and assessing human risk.

This is the second of two reports from the International Workshops on Genotoxicity Testing (IWGT) Working Group on Quantitative Approaches to Genetic Toxicology Risk Assessment (the QWG). The first report summarized the discussions and recommendations of the QWG related to the need for quantitative dose-response analysis of genetic toxicology data, the existence and appropriate evaluation of th...

Determination of genetic toxicity and potential carcinogenicity in vitro--challenges post the Seventh Amendment to the European Cosmetics Directive.

Genetic toxicology and its role in the detection of carcinogens is currently undergoing a period of reappraisal. There is an increasing interest in developing alternatives to animal testing and the three R's of reduction, refinement and replacement are the basis for EU and national animal protection laws the Seventh Amendment to the EU Cosmetics Directive will ban the marketing of cosmetic/pers...

International Conference on Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human Use Ich Harmonised Tripartite Guideline Genotoxicity : a Standard Battery for Genotoxicity Testing of Pharmaceuticals

The Surveillance System of Poliomyelitis/Acute Flaccid Paralysis in the Islamic Republic of Iran: History, Structures and Achievements

Background and Objectives: : According to the global strategy for polio eradication, targeted surveillance of the disease is one of the main tasks of the health system. The purpose of this study was to review the status and surveillance of poliomyelitis/acute flaccid paralysis (AFP) in Iran.   Methods: The present study was a review on the processes, structures and achievements of the poliomy...